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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype

Fig. 3

CD300f-IgG2a increases macrophage infiltration and induces their phenotypic change after a sciatic nerve crush injury. QPCR shows an increase of several cytokines and CD300f at 1 dpl with no differences between treatments (a). Infiltrated macrophages stained by tomato lectin show increased number at 10 and 28 dpl following CD300f-IgG2a treatment (b, c). The macrophage phenotype is altered after CD300f-IgG2a treatment, showing decreased iNOS staining at 10 dpl and increased staining at 28 dpl (d, e: mean grey value). On the contrary, the number of CD206-stained cells shows an important increase at 10 dpl (f, g), but no significant differences at 28 dpl. YFP-regenerated myelinated fibres can be seen in green in b and f. (*p < 0.05 vs. uninjured and IgG2a treatment). Scale bar in b and e: 40 μm

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Journal of Neuroinflammation

ISSN: 1742-2094