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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: CD300f immunoreceptor contributes to peripheral nerve regeneration by the modulation of macrophage inflammatory phenotype

Fig. 4

Tomato lectin stains most of the macrophages in the normal and injured nerve. Single focal plane confocal microscopy showed tomato lectin staining for macrophages in the normal and lesioned nerve. Tomato lectin and Iba-1 labeled the very few resident macrophages of the normal nerve (a-c, arrowhead) and meninges (a-c arrow). An increase of tomato lectin and Iba-1 staining was observed at earlier time points after a crush injury (3 dpl), which peaked at 10 dpl and decreased by 28 dpl (d-l). Most macrophages were stained with both markers (a-l, arrowheads), including big foamy macrophages and some smaller and round macrophages. Interestingly, some cells were only stained with tomato lectin (d-l, white arrows) and other only stained with Iba-1 (d-l, red arrows). Scale bar: 20 μm

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