Fig. 4
From: Natalizumab treatment reduces L-selectin (CD62L) in CD4+ T cells
Longitudinal analysis of CD62L expression in one patient who developed PML and CD62L expression in two other patients during the MS reactivation/IRIS phase of PML. The PML patient was analysed by MRI and by flow cytometry four times during treatment. The value (solid diamond) nearby the threshold (dotted line) was found in July, when MRI was suggestive of PML. In August, PML was diagnosed by detection of 80 copies of JCV in the cerebrospinal fluid, in the absence of clinical manifestation. The black circles identify two patients in the reactivation/IRIS phase, 4 months after PML diagnosis and NTZ withdrawal