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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

Fig. 4

Lower doses of PLX5622 improve cognition in aged 3xTg-AD mice. Fifteen-month-old 3xTg-AD mice were treated for either 6 weeks or 3 months with vehicle or 300 mg/kg PLX5622. ab Animals treated for 6 weeks were assessed using novel place and novel object recognition tasks. Treated mice showed a significant improvement in place recognition as compared to untreated 3xTg-AD mice, but no differences were measured between groups in novel object recognition. ck Animals treated for 3 months were assessed using Morris water maze, novel place recognition, and novel object recognition. ce Morris water maze. Treated mice had significantly faster escape latencies on days 6 and 7 of Morris water maze training and trended towards a faster latency to reach platform and increased platform crosses during the probe trial. f, g Treated mice showed significantly improved place recognition as compared to control mice, but no differences were shown between groups in novel object recognition. hk No differences in open field were detected in either distance traveled (h), average velocity (i), the time spent in the center of the arena (j), or in the time spent in the perimeter of the arena (k). *Indicates significance (p < 0.05) by unpaired Student’s t test. Error bars indicate SEM

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