Fig. 7

Chronic lower-dose CSF1R inhibition prevents microglia associating with plaques. Immunofluorescent staining was performed on 3 months treated and control 3xTg-AD mice for 6E10, which recognizes Aβ plaques and IBA1. a–f Representative 10× images are shown of control and treated mice. g–l Representative 63× images are shown of control and treated mice, centered on an area dense with plaques. m Quantification of the number of microglia associated with a plaque and normalized to plaque diameter revealed a 70 % decrease in treated animals as compared to untreated animals. *Indicates significance (p < 0.05) by unpaired Students t test. Error bars indicate SEM