Fig. 3
From: Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes
Induction profile of Nlrs upon acute injury of the sciatic nerve. Expression profile of Nlrb (a), Nlrp (b), and Nlrc (c) subfamily members during acute nerve injury. d Expression profile of several inflammasome components during acute nerve injury. Data is analyzed using the ΔΔCt method, and mRNA expression levels are expressed relative to the basal condition (0-h time point). The graphs show the pooled data of five independent experiments (mean ± SD). e Cell-type-specific expression of Nlrs in steady state and at day 1 post-injury in the peripheral nerve. Schwann cells, resident macrophages, and monocytes were sorted from the peripheral nerve, and expression of several inflammatory markers was determined by RT-qPCR analysis. Mono D1 monocytes at day 1 post-injury, ResMF D1 resident macrophages at day 1 post-injury, ResMF StSt resident macrophages at steady state, SC D1 Schwann cells at day 1 post-injury, SC StSt Schwann cells at steady state, ND not detectable