Fig. 5

Contextual memory is significantly improved following C5a-peptide vaccination. A CFC test was performed with AFF1 (n = 23), AFF2 (n = 23), and control (n = 14) immunized Tg2576 mice, as well as wt littermates (n = 12), all at the age of 15 months. Mice were exposed to electric foot shocks and the memory to recall these shocks was assessed by the percent time freezing in a 2-min interval. Bars represent the group means ± SEM of n animals. The p value was determined using one-way ANOVA test followed by a Dunn’s multiple comparison Test (non-parametric test). The p values are expressed as ^* p < 0.05 and ^** p < 0.01