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Table 1 Morphological parameters of mitochondria analyzed by transmission electron microscopy

From: The disruption of mitochondrial axonal transport is an early event in neuroinflammation

Parameter Meaning
Mitochondrial area Total area of each mitochondrion
External perimeter Mitochondrial external perimeter
Feret’s diameter Longest distance between any two points of the mitochondrial external perimeter
Circularity Two-dimensional sphericity index. A value of 1 corresponds to a perfect sphere. \( \mathrm{Circ}=\frac{4\uppi \times \kern0.37em \mathrm{Area}}{{\left(\mathrm{Perimeter}\right)}^2} \)
Roundness Two-dimensional sphericity index. A value of 1 corresponds to a perfect sphere. \( \mathrm{Round}=\frac{4\kern0.37em \times \kern0.37em \mathrm{Area}}{\uppi {\left(\mathrm{minoraxis}\right)}^2} \)
Aspect ratio (AR) Ratio between the major and the minor axis of a mitochondrion. \( \mathrm{A}\mathrm{R}=\frac{\mathrm{Major}\ \mathrm{Axis}}{\mathrm{Minor}\ \mathrm{Axis}} \)
Cristae perimeter/external perimeter Ratio between the mitochondrial cristae perimeter and the external perimeter. Reflects the complexity of mitochondrial cristae
  1. Description of the morphological mitochondrial parameters analyzed by TEM [21, 22]