Table 1 Morphological parameters of mitochondria analyzed by transmission electron microscopy
From: The disruption of mitochondrial axonal transport is an early event in neuroinflammation
Parameter | Meaning |
|---|---|
Mitochondrial area | Total area of each mitochondrion |
External perimeter | Mitochondrial external perimeter |
Feret’s diameter | Longest distance between any two points of the mitochondrial external perimeter |
Circularity | Two-dimensional sphericity index. A value of 1 corresponds to a perfect sphere. \( \mathrm{Circ}=\frac{4\uppi \times \kern0.37em \mathrm{Area}}{{\left(\mathrm{Perimeter}\right)}^2} \) |
Roundness | Two-dimensional sphericity index. A value of 1 corresponds to a perfect sphere. \( \mathrm{Round}=\frac{4\kern0.37em \times \kern0.37em \mathrm{Area}}{\uppi {\left(\mathrm{minoraxis}\right)}^2} \) |
Aspect ratio (AR) | Ratio between the major and the minor axis of a mitochondrion. \( \mathrm{A}\mathrm{R}=\frac{\mathrm{Major}\ \mathrm{Axis}}{\mathrm{Minor}\ \mathrm{Axis}} \) |
Cristae perimeter/external perimeter | Ratio between the mitochondrial cristae perimeter and the external perimeter. Reflects the complexity of mitochondrial cristae |