Fig. 4

serpina3n significantly reduces axonal injury without interfering in the infiltration of CD4⁺ and CD8⁺ T cells to the CNS. Non-phosphorylated SMI32 positive axons in tissue sections from a untreated control group, e serpina3n treated group. b Number of infiltrating CD4⁺ T cells into the lumbar sections of untreated control mice and f Infiltrating CD4⁺ T cells in serpina3n-treated mice. c and g DAPI-stained cells in untreated control and serpina3n-treated groups, respectively. d Merged micrograph from panels a, b, and c. h Merged micrograph from panels e, f, and g. (Scale bars, 50 μm). i Quantification of SMI32-positive axons in the control and serpina3n-treated groups (P < 0.05). j Quantification of infiltrating CD4⁺ T cells in the control and serpina3n-treated groups