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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo

Fig. 4

serpina3n significantly reduces axonal injury without interfering in the infiltration of CD4+ and CD8+ T cells to the CNS. Non-phosphorylated SMI32 positive axons in tissue sections from a untreated control group, e serpina3n treated group. b Number of infiltrating CD4+ T cells into the lumbar sections of untreated control mice and f Infiltrating CD4+ T cells in serpina3n-treated mice. c and g DAPI-stained cells in untreated control and serpina3n-treated groups, respectively. d Merged micrograph from panels a, b, and c. h Merged micrograph from panels e, f, and g. (Scale bars, 50 μm). i Quantification of SMI32-positive axons in the control and serpina3n-treated groups (P < 0.05). j Quantification of infiltrating CD4+ T cells in the control and serpina3n-treated groups

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