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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo

Fig. 5

serpina3n significantly reduces inflammatory cell-mediated axonal death. In the untreated control group, representative micrographs showing SMI32/312 immuno-reactive (a and c) and DAPI-stained (b and d) sections in the lumbar cord of the dorsal (a and b) and ventral columns (c and d). In the serpina3n-treated group, representative micrographs showing SMI32/312 immuno-reactive (e and g) and DAPI-stained (f and h) sections in the lumbar cord of the dorsal (e and f) and ventral columns (g and h). Arrows indicate the lesion area or “black hole”. (Scale bars, 50 μm). i This graph shows that the percentage of lesion area/total area of the columns is significantly bigger in the untreated control group when compared to serpina3n-treated group (P < 0.05). j and k serpina3n reduces the magnitude of demyelination. Eriochrome cyanin-stained representative sections showing the scale of demyelination in untreated control (j) and serpina3n-treated (k) groups, respectively

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