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Table 3 Neuropathology quantification of the EAE model induced with rhMOG/IFA

From: Immune profile of an atypical EAE model in marmoset monkeys immunized with recombinant human myelin oligodendrocyte glycoprotein in incomplete Freund’s adjuvant

 

Spinal cord

Brain

Monkey

Inflammation/mm2a

Demyelination (%)

Demyelination WM (%)

Demyelination GMb

M08001

0.0

0.0

0.0

M08093

2.9

32.0

12.0

±; Intracortical

M08119

0.3

1.0

0.2

M09047

0.1

5.4

6.5

±; Intracortical

M09064

0.7

7.9

1.3

M09083

0.4

4.2

0.1

±; Intracortical

  1. aThe inflammatory index of the spinal cord is defined as the average number of inflamed blood vessels/spinal cord cross sections. In total, eight slices for each animal were stained, which equals 6 cm2 in total
  2. bDemyelination in brain GM was quantified as: + = demyelination; ± = some demyelination; − = no demyelination