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Table 3 Neuropathology quantification of the EAE model induced with rhMOG/IFA

From: Immune profile of an atypical EAE model in marmoset monkeys immunized with recombinant human myelin oligodendrocyte glycoprotein in incomplete Freund’s adjuvant

  Spinal cord Brain
Monkey Inflammation/mm2a Demyelination (%) Demyelination WM (%) Demyelination GMb
M08001 0.0 0.0 0.0
M08093 2.9 32.0 12.0 ±; Intracortical
M08119 0.3 1.0 0.2
M09047 0.1 5.4 6.5 ±; Intracortical
M09064 0.7 7.9 1.3
M09083 0.4 4.2 0.1 ±; Intracortical
  1. aThe inflammatory index of the spinal cord is defined as the average number of inflamed blood vessels/spinal cord cross sections. In total, eight slices for each animal were stained, which equals 6 cm2 in total
  2. bDemyelination in brain GM was quantified as: + = demyelination; ± = some demyelination; − = no demyelination