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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: An N-terminal antibody promotes the transformation of amyloid fibrils into oligomers and enhances the neurotoxicity of amyloid-beta: the dust-raising effect

Fig. 1

An N-terminal antibody promotes the disaggregation of preformed Aβ fibrils. a Representative TEM images of Aβ fibrils after treatment with antibodies targeting different sequences of Aβ. b Quantification of the fibrillar area fractions of TEM images. **P < 0.01 vs PBS. c Fluorescence intensity of the ThT assays showing the capacity of antibodies to disaggregate preformed Aβ fibrils. Aβ42 monomers were aggregated for 48 h and were then incubated with antibodies or PBS for an additional 72 h for disaggregation. **P < 0.01. d Western blot image showing the capacity of antibodies to disaggregate preformed Aβ fibrils. e Quantification of the relative intensity of western blot bands. **P < 0.01 vs control, #P < 0.05 and ##P < 0.01 vs PBS. TEM transmission electron microscopy, ThT thioflavin T

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