Fig. 2

Clinical course of chronic MOG-EAE in 14-3-3 γ knockout mice is more severe. Clinical course of MOG 35-55-induced EAE in 14-3-3 γ-deficient mice (gray curve) and C57BL/6 control mice (black curve). Data are pooled from three different experiments (n = 20 vs. 19 mice per group). Onset of disease is not different between both groups. After the first maximum of EAE in wild-type mice at day 15 p.i.; 14-3-3 γ mice display a more severe course of disease until day 20 p.i.. This enhanced disease severity is maintained in the later disease phase until day 56 p.i., while controls slightly improve over time (*p < 0.05)