Fig. 2

Postnatal alcohol exposure (PAE) induced alterations in gait and deficits in fear conditioning. a–f Animals aged P45–50 were placed on a Catwalk apparatus and differences in gait were assessed (n = 9 animals from 4 litters). a Representative Catwalk images are shown illustrating a PAE-induced reduction in overlap between the position of front and hind paws (LF left forepaw, LH left hindpaw, RF right forepaw, RH right hindpaw). Summary graphs illustrating the overall effect of PAE on the distance between placement of fore and hind paws on the right (b) and left (c) side of the body. d–f Phase dispersions, which are indicators of inter-limb coordination, were measured between paws. g–h Animals aged P36–48 (n = 5–7 animals from 5–7 litters) were tested for performance on a variation of the fear conditioning test in which they were pre-exposed to the context the day before being re-exposed to the context and then shocked. (*p < 0.05, **p < 0.01, ***p < 0.001)