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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Deep brain stimulation induces antiapoptotic and anti-inflammatory effects in epileptic rats

Fig. 1

DBS, apoptosis, and neuroinflammation. (a) Hippocampal caspase 3 activity was increased in pilocarpine-treated rats undergoing SE (P = 0.009; vs saline controls), an effect that was significantly reversed in the DBS-treated Pilo group (P = 0.02; vs Pilo). Similarly (b), hippocampal levels of the pro-inflammatory IL-6 were significantly increased after SE (P = 0.006; vs saline-injected controls), an effect that was countered by the administration of AN DBS (P = 0.02; vs Pilo). In contrast, SE-induced increases in TNFα (P = 0.0003 vs saline-injected controls) were not influenced by DBS (c). # indicates differences from control, *indicates differences from Pilo

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