Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury

Fig. 1

Composite neuroscore (mean ± SEM). Evaluation of neuromotor function and recovery over a 30-day period. At 24 h post-TBI, injured WT mice (n = 3) demonstrated a significant decline in neuromotor function compared with sham WT (n = 4) and CX3CR1−/− injured mice (n = 4; two-way ANOVA, F (1, 9) **p = 0.001; **p = 0.001). At 7 days post-TBI, injured WT mice (n = 5) continued to demonstrate significant impairment than sham WT mice (n = 5; two-way ANOVA, F (1, 15) *p = 0.01). Injured CX3CR1−/− mice (n = 4) were not different from the injured WT mice (p > 0.05). A significant impairment in motor function performance was still present at 15 days post-injury in injured WT mice (n = 8) compared to sham WT mice (n = 8; two-way ANOVA, F (1, 15) **p = 0.001;). Injured CX3CR1−/− mice (n = 8) were not different from the injured WT mice (n = 8; p > 0.05). All injured mice (n = 5) recovered similarly at 30 days post-TBI. White bar = CX3CR1 sham WT. Green bar = CX3CR1 sham KO. Red Bar = CX3CR1 WT-TBI. Blue bar = CX3CR1 KO-TBI

Back to article page