Fig. 3
From: Fingolimod induces neuroprotective factors in human astrocytes
FTY-P blocks TNF-induced expression of proinflammatory and antiviral factors. Human U373 astrocytoma cells were treated with FTY-P (1 μM) and 1 h later with different concentrations of TNF (0.005; 0.125 μg/ml). Expression of CXCL10, BAFF, MX1, and OAS2 was determined 8 h later by qPCR (values normalized to the untreated control samples; mean ± SEM of seven independent biological replicates; two-tailed Wilcoxon signed rank test)