Fig. 2
From: NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats
a Downstream analysis of Wnt-related gene expression from aged animals predicts a decrease in cell viability and transcription of RNA. b Analysis of upstream regulators of cytokine expression in animals supplemented with NT-020 predicts a decrease in the activity of the p65 subunit of NF-κB (RELA) and an increase in corticosterone activity as determined by the concordant activity of their identified downstream targets. c Downstream analysis of gene expression predicts a decrease in NO synthesis, TH1 immune response, and influx of granulocytes as a result of the modulation in indicated gene activity. d Upstream analysis of the Wnt pathway predicts inhibited activity of Sonic Hedgehog (SHH) and EGF receptor