Table 1 Expression of cytokines and chemokines in aged brain
From: NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats
Gene symbol | Gene name | p value | Fold change | Function |
|---|---|---|---|---|
Ccl19 | Chemokine ligand 19 | 0.03 | 1.868 | Basal leukocyte migration |
Ccl2 | Chemokine ligand 2 | 0.042 | 1.829 | T lymphocytes/monocytes |
Ccl3 | Chemokine ligand 3 | 0.003 | 3.304 | Monocytes/macrophages |
Ccl4 | Chemokine ligand 4 | 0.03 | 5.936 | Natural killer cells/monocytes |
Ccl5 | Chemokine ligand 5 | 0.001 | 16.009 | T cells/eosinophils |
Cxcl10 | Chemokine ligand 10 | 0.011 | 4.271 | Multiple |
Cxcl11 | Chemokine ligand 11 | 0.001 | 3.302 | T cells |
Xcl1 | Chemokine ligand 1 | 0.026 | 2.331 | T cells |
Il16 | Interleukin 16 | 0.012 | −1.951 | CD4+ T cells |
Tnf | Tumor necrosis factor | 0.029 | 1.494 | Pro-inflammatory |
Il1a | Interleukin 1, alpha | 0.009 | 2.458 | Pro-inflammatory |
Il1b | Interleukin 1, beta | 0.006 | 4.074 | Pro-inflammatory |
Il15 | Interleukin 15 | 0.009 | 1.669 | Pro-inflammatory |
Ltb | Lymphotoxin beta | 0.043 | 1.583 | Pro-inflammatory |
Il24 | Interleukin 24 | 0.001 | −2.925 | Anti-inflammatory |
Il1rn | Interleukin 1, receptor antagonist | 0.001 | 5.644 | Anti-inflammatory |