Fig. 1

Schematic representation of study design and body weight change in Mif ^−/− mice and WT littermates. a Female mice aged 3-6 months received intracerebroventricular (ICV) injection of either saline or 3.0 mg/kg STZ on day 0. Mice were weighed once every 7 days until day 42, when mice were sacrificed and hippocampus, cerebral cortex and brain sections were prepared for further biochemical studies. The body weight of WT and Mif ^−/− mice receiving STZ or saline was recorded and shown in (b) and (c), respectively. Each group contained 6-8 mice and the data shown are the means ± SEM. *p < 0.05 compared with controls