Fig. 3

Coronal T1- and T2-weighted image with associated immuno-histochemistry of ex vivo fetal sheep brain exposed to lipopolysaccharide. a T1 hyperintensity (arrowhead) with b histological staining using ionized calcium binding adaptor molecule 1 (Iba1) in the corresponding area (arrowhead). c At higher magnification, the area shows dense macrophage-like microglia within the core of the periventricular white matter lesions (arrowhead). Microglia surrounding the core lesion demonstrates amoeboid/activated morphology (black arrow). The dotted line delineates the core of the lesion from the surrounding tissue. a and b are adapted from [105]