The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients

Table 3 Correlations of the parameters studied with PREP levels in plasma of cirrhosis and control subjects

Parameter	Correlation statistical parameters
PHES	r = ns
PHES	p = ns
Child-Pugh	r = −0.484
Child-Pugh	p = <0.001
MELD	r = −0.377
MELD	p = 0.004
Creatinine	r = ns
Creatinine	p = ns
Total bilirubin	r = −0.281
Total bilirubin	p = 0.031
Albumin	r = 0.362
Albumin	p = 0.007
INR	r = ns
INR	p = ns
IL-6	r = −0.467
IL-6	p = 0.001
IL-18	r = −0.295
IL-18	p = 0.039
cGMP plasma	r = −0.333
cGMP plasma	p = 0.019
Lymphocyte basal cGMP	r = 0.431
Lymphocyte basal cGMP	p = 0.003
SNAP-induced cGMP	r = −0.413
SNAP-induced cGMP	p = 0.003
Nitrates + nitrites	r = ns
Nitrates + nitrites	p = ns
ANP	r = ns
ANP	p = ns
Ammonia	r = ns
Ammonia	p = ns

rPearson correlation coefficient, PREP prolyl oligopeptidase, FAP fibroblast associated protein, DTT dithiothreitol, PHES Psychometric Hepatic Encephalopathy Score, IL-6 interleukin-6, IL-18 interleukin-18, ANP atrial natriuretic peptide, MELD model end-stage liver disease, ns not significant

ISSN: 1742-2094