Skip to main content

Advertisement

Table 3 Correlations of the parameters studied with PREP levels in plasma of cirrhosis and control subjects

From: The expression levels of prolyl oligopeptidase responds not only to neuroinflammation but also to systemic inflammation upon liver failure in rat models and cirrhotic patients

Parameter Correlation statistical parameters
PHES r = ns
p = ns
Child-Pugh r = −0.484
p = <0.001
MELD r = −0.377
p = 0.004
Creatinine r = ns
p = ns
Total bilirubin r = −0.281
p = 0.031
Albumin r = 0.362
p = 0.007
INR r = ns
p = ns
IL-6 r = −0.467
p = 0.001
IL-18 r = −0.295
p = 0.039
cGMP plasma r = −0.333
p = 0.019
Lymphocyte basal cGMP r = 0.431
p = 0.003
SNAP-induced cGMP r = −0.413
p = 0.003
Nitrates + nitrites r = ns
p = ns
ANP r = ns
p = ns
Ammonia r = ns
p = ns
  1. rPearson correlation coefficient, PREP prolyl oligopeptidase, FAP fibroblast associated protein, DTT dithiothreitol, PHES Psychometric Hepatic Encephalopathy Score, IL-6 interleukin-6, IL-18 interleukin-18, ANP atrial natriuretic peptide, MELD model end-stage liver disease, ns not significant