Fig. 3

HSF1 inhibition attenuates IFN-γ-induced iNOS expression in BV-2 cells. a Effect of KRIBB11 pretreatment (30 min, 3 μM) on iNOS protein expression in IFN-γ-stimulated BV-2 cells. b Quantitative analysis of the effect of KRIBB11 on iNOS protein expression in IFN-γ-stimulated cells (n = 3, **P < 0.01 vs. control group). c Effect of KRIBB11 (30 min, 3 μM) pretreatment on iNOS protein expression in IFN-γ-stimulated (24 h) primary microglia. d Quantitative analysis of the effect of KRIBB11 on iNOS protein expression in IFN-γ-stimulated primary microglia (n = 3, **P < 0.01 vs. control or IFN-γ alone-treated group). e Quantitative analysis of the mRNA level of iNOS in primary microglia upon IFN-γ treatment in the absence or presence of KRIBB11 (n = 3, *P < 0.05 vs. IFN-γ alone-treated group, **P < 0.01 vs. control group). All data were shown as mean ± S.E. NS, no significance