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Fig. 12 | Journal of Neuroinflammation

Fig. 12

From: P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

Fig. 12

Effects of FeTPPS on NLRP3 inflammasome activation and IL-1β/IL-18 maturation. RT-PCR of NLRP3 after FeTPPS treatment 24 h following ICH, n = 6 rats per group (a). Western blot (d, b) showed that FeTPPS significantly reduced striatal 3-NT expression 24 h after ICH compared with the Vehicle group. Western blot assay (g) and quantification of NLRP3 (c), ASC (e), caspase-1 p20 subunit (f), mature IL-1β (h), and mature IL-18 (j) after FeTPPS treatment 24 h following ICH, n = 5 rats per group. Data represent means ± SD. * P < 0.05, ** P < 0.01. ASC adaptor protein apoptosis-associated speck-like protein containing a CARD, GAPDH glyceraldehyde 3-phosphate dehydrogenase, ICH intracerebral hemorrhage, IL interleukin, NLRP3 pyrin domain-containing 3, 3-NT 3-nitrotyrosine

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