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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

Fig. 4

Effects of P2X7R siRNA on NLRP3 inflammasome activation and IL-1β/IL-18 maturation after ICH. RT-PCR of NLRP3 after P2X7R siRNA treatment 24 h following ICH (a), n = 6 rats per group. Western blot assay (b) and quantification of NLRP3 (c), ASC (d), caspase-1 p20 subunit (e), IL-1β (f), and IL-18 (g) after P2X7R siRNA treatment 24 h following ICH, n = 4 rats per group. Data represent means ± SD. ** P < 0.01 vs. Sham, @ P < 0.05 vs. Vehicle, # P < 0.05 vs. ICH + Scramble siRNA. ASC adaptor protein apoptosis-associated speck-like protein containing a CARD, GAPDH glyceraldehyde 3-phosphate dehydrogenase, ICH intracerebral hemorrhage, IL interleukin, NLRP3 The NLR family, pyrin domain-containing 3

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Journal of Neuroinflammation

ISSN: 1742-2094