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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

Fig. 7

Effects of BBG on NLRP3 inflammasome activation and IL-1β/IL-18 maturation. RT-PCR of NLRP3 after BBG treatment 24 h following ICH, n = 6 rats per group (a). Representative western blot (b) and therapeutic effects of BBG on P2X7R (c), NLRP3 (d), ASC (e), caspase-1 p20 subunit (f), mature IL-1β (g), and mature IL-18 (h) levels in the ipsilateral hemisphere 24 h after ICH, n = 4 rats per group. Data represent means ± SD. * P < 0.05, ** P < 0.01. ASC adaptor protein apoptosis-associated speck-like protein containing a CARD, BBG brilliant blue G, GAPDH glyceraldehyde 3-phosphate dehydrogenase, ICH intracerebral hemorrhage, IL interleukin, NLRP3 pyrin domain-containing 3

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Journal of Neuroinflammation

ISSN: 1742-2094