Fig. 1From: Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord responseGenetic analysis of Cr2 expression following ventral root avulsion. Regulation of Cr2 expression following VRA is under strong genetic control. Global expressional profiling of injured spinal cords from a F2(DAxPVG) rat intercross (n = 144) reveals a cis-acting expression QTL at the end of chromosome 13 (a–b the black box marks the genetic area around D13Rat49 subsequently fine-mapped in the G12). D13Rat49 PVG alleles are associated with higher Cr2 expression (c). The cis-acting control of Cr2 expression after nerve injury was confirmed in a G12(DAxPVG) advanced intercross line (n = 163) (d). Again, PVG alleles gave rise to higher expression (e). A kinetic study of the injury response in DA and PVG animals with different post-operative survival following VRA revealed that Cr2 is expressed at very low levels in naïve spinal cord but strongly up regulated following injury, particular in PVG (f). n = 5–7 per strain per time-point following VRA. LOD > 3.3 corresponds to p < 0.0001, *p < 0.05, **p < 0.01, and ***p < 0.001. In c and d, the results are presented as mean ± SD and in f as mean ± SEMBack to article page