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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response

Fig. 1

Genetic analysis of Cr2 expression following ventral root avulsion. Regulation of Cr2 expression following VRA is under strong genetic control. Global expressional profiling of injured spinal cords from a F2(DAxPVG) rat intercross (n = 144) reveals a cis-acting expression QTL at the end of chromosome 13 (a–b the black box marks the genetic area around D13Rat49 subsequently fine-mapped in the G12). D13Rat49 PVG alleles are associated with higher Cr2 expression (c). The cis-acting control of Cr2 expression after nerve injury was confirmed in a G12(DAxPVG) advanced intercross line (n = 163) (d). Again, PVG alleles gave rise to higher expression (e). A kinetic study of the injury response in DA and PVG animals with different post-operative survival following VRA revealed that Cr2 is expressed at very low levels in naïve spinal cord but strongly up regulated following injury, particular in PVG (f). n = 5–7 per strain per time-point following VRA. LOD > 3.3 corresponds to p < 0.0001, *p < 0.05, **p < 0.01, and ***p < 0.001. In c and d, the results are presented as mean ± SD and in f as mean ± SEM

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