Fig. 2

Gene expression network of transcripts regulated from D13Rat49 in the F2(DAxPVG) intercross. A co-expression gene network was constructed from all transcripts regulated from D13Rat49. All 31 genes regulated from D13Rat49 were closely interconnected; the association between the genes is based on pair-wise co-variation of expression levels. Cis-regulated genes are marked with red circles, the other genes are regulated in trans. The Cr2 transcript is surrounded by a green ring. Cr2 expression correlated negatively with expression of multiple genes with pro-inflammatory action, for example CD48, CD244, F11r, and Fcgr2a all involved in lymphocyte activation. Conversely, Cr2 expression correlated positively with Sgpl1 and Meis3, genes involved in anti-inflammatory and cellular survival processes. n = 144 F2(DAxPVG) rats