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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response

Fig. 3

Glial activation in DA and PVG rats following sciatic nerve transection. Sciatic nerve transaction in DA and PVG rats leads to increased Gfap expression without discernible strain differences (a). Quantification of GFAP immunoreactivity in the dorsal spinal motor nucleus demonstrates more pronounced astrocyte activation in the PVG compared to DA strain (b–d). More intense microglia activation occurs in the DA strain following SNT, as assessed by expression of Mrf-1 and CD11b (e–f), as well as by quantifying Iba1 immunoreactivity (g–j). IL ipsilateral, CL contralateral. Scale bar equals 40 μm. n = 5 + 5 RT-PCR, 6 + 6 IHC; *p < 0.05, **p < 0.01, and ***p < 0.001. The results are represented as mean ± SEM

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