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Table 1 IL-1β, TNF-α, and IL-10 contents are increased in hippocampus of PCS rats and are normalized by treatment with sildenafil

From: Sildenafil reduces neuroinflammation and restores spatial learning in rats with hepatic encephalopathy: underlying mechanisms

Hippocampus

Sham

Sham + SILD

PCS

PCS + SILD

TNF-α

100 ± 17

125 ± 13

144 ± 9*

103 ± 7aa

n = 9

n = 10

n = 9

n = 9

IL-1β

100 ± 7

108 ± 10

149 ± 19*

88 ± 12a

n = 12

n = 13

n = 12

n = 12

IL-4

100 ± 9

109 ± 14

112 ± 12

93 ± 13

n = 10

n = 10

n = 10

n = 11

IL-10

100 ± 11

106 ± 7

144 ± 13*

105 ± 10a

n = 11

n = 11

n = 10

n = 10

  1. Values are the mean ± SEM of the number of rats indicated (n). Values significantly different from sham rats are indicated by asterisks. Values significantly different from PCS rats not treated with sildenafil are indicated by a
  2. *p < 0.05; a p < 0.05; aa p < 0.01