Fig. 2

Chimeric MRL/+ → MRL/lpr mice display a behavioral phenotype consistent with MRL/lpr → MRL/lpr mice. All transplanted murine strains displayed an equivalent exploratory drive (a) and locomotion (b, c). An increased ratio of center track/total track, an indicator of increased risk seeking behavior, was found in MRL/+ → MRL/lpr, MRL/lpr → MRL/lpr, and MRL/lpr mice (d). While there were no significant differences between mice on object recognition tasks (e), MRL/+ → MRL/lpr (p < 0.05) and MRL/lpr → MRL/lpr (p < 0.05) displayed significantly poorer performance on spatial memory tasks as compared to MRL/+ → MRL/+ mice (f). The forced swim test demonstrated marked depression-like behavior in MRL/+ → MRL/lpr mice, similar to that seen in MRL/lpr → MRL/lpr and MRL/lpr mice (g). Immobility was not seen in MRL/+ → MRL/+ and MRL/+ mice. Error bars = SEM, *p < 0.05, **p < 0.01, ****p < 0.0001