Table 1 Antibody titers and renal function of chimeric and unmanipulated mice
Table 1 | Total IgG (mg/dL) | Anti-DNA antibodies (O.D./MRL/+) | BUN (mg/dL) | Urinary albumin/creatinine (ratio) | Total renal inflammatory score | Renal deposits | Renal endocapillary proliferation | Renal crescents | Renal tabular casts | Renal interstitial inflammation |
|---|---|---|---|---|---|---|---|---|---|---|
MRL/+ → MRL/+ | 0.99*** | 1.13*** | 0.76** | 1.41 | 0.37*** | 0.67*** | 1.00** | 0.00 | 0.17* | 0.00*** |
MRL/lpr → MRL/lpr | 4.56 | 4.17 | 1.10 | 12.20 | 1.60 | 2.57 | 2.71 | 0.44 | 1.00 | 1.29 |
MRL/+ → MRL/lpr | 1.32** | 2.40*** | 0.88 | 1.72 | 0.67** | 1.09** | 1.37* | 0.00 | 0.45 | 0.45** |
MRL/+ | 1.00 | 1.00 | 1.00 | 1.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
MRL/lpr | 1.86## | 4.38### | 1.41 | 29.84### | 1.60### | 2.80### | 2.80### | 0.40 | 0.60 | 1.40### |