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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: MicroRNA367 negatively regulates the inflammatory response of microglia by targeting IRAK4 in intracerebral hemorrhage

Fig. 6

miR-367 inhibited inflammation response and improved neurological injury in vivo. Mice were received an intracerebral ventricular injection of miR-367 mimics or miR-367 control 10 min after ICH and sacrificed 48 h after ICH. The brains were dissected. a The mRNA levels of miR-367 were assayed by qRT-PCR assay. b Western blotting was used to evaluate IRAK4, NF-κB p65, IL-6, IL-1β, and TNF-α expression of brain tissues. c The cerebral water content of mice was analyzed. d The neurological deficit tests were determined by neurological severity scores, a composite of motor, sensory, reflex, and balance tests. Neurological function was graded on a scale of 1 to 18, and repeated three times. Experiments performed in triplicate showed consistent results. Data are presented as the mean ± SD of three independent experiments. *P < 0.05

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