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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Self-reactive CD4+ T cells activated during viral-induced demyelination do not prevent clinical recovery

Fig. 4

MHC class II expression and exogenous myelin antigen presentation by CNS-infiltrating CD11b+ cells and microglia. a Percentage and mean fluorescence intensity (MFI) expression of MHC class II by CNS-derived control (CD45hiCD11b), infiltrating CD11b+ (CD45hiCD11b+), and microglia (CD45lowCD11b+) cells between days 7 and 30 p.i. Data represent the average ± SEM of three separate experiments with n = 3 pooled mice per experiment. Histogram of MHC class II expression by CD45hiCD11b (black line), infiltrating CD11b+ (red line), and microglia (blue line) during JHMV infection. b MFI expression of CD80 and CD86 by CNS-infiltrating CD11b+ (CD45hiCD11b+) and microglia (CD45lowCD11b+) cells between days 7 and 30 p.i. Data represent the average ± SEM of 3 separate experiments with n = 3 pooled mice per experiment. c Proliferation of 2D2 CD4+ T cells co-cultured with CD45hiCD11b+ and CD45lowCD11b+ cells with or without exogenously added MOG35-55 peptide

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