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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia

Fig. 3

Mice lacking IFN-β show an increase in the fraction of circulating B220+ (immature) B cells 2 days after tMCAo. PBMCs were isolated 2 days after tMCAo (WT, n = 9; IFN-βKO, n = 11), as well as 8 days after tMCAo (WT, n = 6–7; IFN-βKO, n = 7–8) and sham surgery (n = 4 for each genotype). Inflammatory and immune cell subsets were analyzed by FLC. a Percentages of CD11b+ and b MHCII+ (activated) CD11b+ cells within PBMCs. c Dot plot illustrating gating for CD3NK1.1+ versus CD3+NK1.1+ cells (NK and NKT cells, respectively). d Percentage of NK and e NKT cells within PBMCs. f Percentages of B220+ (immature) and g B220+MHCII+ (mature and activated) B cells in the PBMCs pool. *p < 0.05, **p < 0.01, and **p < 0.001 (Bonferroni correction). Note that stroke led to a decrease in the percentages of NK and NKT cells 8 days after tMCAo in relation to sham surgery (#p < 0.05, two-way ANOVA, for NK cells) and 2 days post-occlusion (##p < 0.001, two-way ANOVA, for NK and NKT cells)

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