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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Matrix-derived inflammatory mediator N-acetyl proline-glycine-proline is neurotoxic and upregulated in brain after ischemic stroke

Fig. 1

Ac-PGP induces apoptosis in primary cortical neurons. a Apoptosis in vehicle- and ac-PGP-treated neurons was measured by TUNEL assay 24 h after treatment. Nuclei were stained with 4',6-diamidino-2-phenylindole (DAPI). Neurons are indicated by microtubule-associated protein 2 (MAP2) staining. b Graphical representation of actual data shown in a. A statistically significant difference in apoptosis was found between vehicle and 0.1, 1, 10, and 100 nM ac-PGP (*p < 0.05 to p < 0.0001) and between 10 nM and 0.01, 0.1, and 1 nM ac-PGP (# p < 0.0001 to p < 0.05). c A control ac-PGG peptide did not induce significant apoptosis in neurons at doses up to 100 nM

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