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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Matrix-derived inflammatory mediator N-acetyl proline-glycine-proline is neurotoxic and upregulated in brain after ischemic stroke

Fig. 2

CXCR2 antagonist SB225002 and CXCR2 antibody protect neurons against ac-PGP-induced apoptosis. a Cells exposed to 10 nM ac-PGP for 24 h were first pretreated with SB225002 or anti-CXCR2 ligand-binding domain antibody for 30 min at the indicated dose. Cells pretreated with all doses of SB225002 were significantly less apoptotic than cells treated with ac-PGP only (*p < 0.0001). Cells pretreated with 1 nM SB225002 were significantly less apoptotic than cells treated with 0.01 and 0.1 nM SB225002 (# p = 0.0001 to p < 0.05). b Cells pretreated with CXCR2 antibody at a 1:1000 (1e3) or greater dilution exhibited significantly less apoptosis than cells treated with ac-PGP alone (*p < 0.0001) while a 1e3 dilution produced significantly less apoptosis than a 1e2 dilution (# p < 0.0001)

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