Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS

Table 1 Association analyses of the MS severity score and APOE polymorphisms rs429358 and rs7412

Stratum (N)	SNP	β _add	p _add, p _add-emp	β _rec	p _rec, p _rec-emp
All (3237)	rs7412	−0.025	0.824, 0.323	0.010	0.985, 0.453
	rs429358	0.115	0.220, 0.739	0.841	0.0140, 0.774
Women (2290)	rs7412	0.023	0.865, 0.460	0.091	0.883, 0.384
	rs429358	0.221	0.0464, 0.357	0.971	0.0170, 0.765
Men (947)	rs7412	−0.117	0.571, 0.539	−0.009	0.993, 0.923
	rs429358	−0.180	0.302, 0.302	0.446	0.482, 0.998

Linear regression analyses of the MS severity score (MSSS) and APOE rs7412 and rs429358 were performed across 3237 MS patients as well as after stratification for sex
N number, SNP single-nucleotide polymorphism, add additive model, rec recessive model, emp p value obtained after 10,000 rounds of permutation. β corresponds to the effect estimated for the minor allele of rs7412 (T) and rs429358 (C), respectively

ISSN: 1742-2094