Fig. 6

Light exposure and minocycline exert global effects on the retinal transcriptome. a Gene Expression Dynamics Inspector (GEDI) analysis of the complete RNA-seq dataset (Gene Expression Omnibus Series Nr. GSE71025) from control retinas and light-exposed retinas in the absence or presence of minocycline. Biological duplicates were analyzed for each condition and the pseudo-color scale indicates high (red) or low (blue) expression levels. b, c DESeq2 analysis to determine differential gene expression between the indicated groups using a log2 fold change cutoff of ≥2 and ≤−2. The MA-plots demonstrate that light exposure caused a global induction of 217 genes (b), whereas light exposure plus minocycline administration reversed this effect with many counter-regulated transcripts (c)