Fig. 4

Relative mRNA expression profiles of IL-1β, TNF-α, IL-6, COX-2, and iNOS in the hypothalamus. The loss of PKR had little effect on inflammatory gene expression in the hypothalamus after E. coli challenge. n = 7–8 per group at 4 h, n = 6–8 per group at 48 h, and n = 9–11 per group at the 120 h time point. *p < 0.05, **p < 0.01, ***p < 0.001