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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

Fig. 6

Effects of LPS on TEER of BMECs and cytoarchitecture of ZO-1, claudin-5, and occludin. Panels a and b show that LPS added either 24 or 48 h earlier to monocultures of BMECs decreased their TEER in a dose-dependent manner, consistent with disruption of the BBB. Immunostaining for ZO-1 shows increasing dose-dependent cytoarchitectural disorganization for ZO-1 (panels c–f). Immunostaining for claudin-5 (panels g and h) does not clearly show such disorganization, whereas immunostaining for occludin does (panels i and j). *p < 0.05; ***p < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094