Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

Table 1 Effects of LPS on BBB disruption by brain region. Mice were studied 24 h after a 3 mg/kg dose of LPS given IP. Means ± SEM

Region	Control (n = 9; in units of μl/g)	LPS (n = 10; in units of μl/g)	% Change	Significance^a
Olfactory bulb	34.5 ± 3.4	43.5 ± 3.8	26	t
Frontal cortex	6.6 ± 0.8	10.3 ± 1.0	55	*
Occipital cortex	11.5 ± 0.9	13.9 ± 1.2	20	NS
Parietal cortex	9.2 ± 0.6	12.5 ± 0.8	36	**
Striatum	14.0 ± 0.8	19.9 ± 2.0	42	*
Midbrain	10.6 ± 0.6	15.0 ± 1.2	41	**
Thalamus	8.6 ± 0.5	13.4 ± 0.9	56	***
Cerebellum	9.4 ± 0.6	14.3 ± 1.2	52	**
Pons-medulla	12.2 ± 0.6	18.8 ± 1.4	54	***
Hippocampus	10.0 ± 0.6	15.0 ± 1.2	50	**
Hypothalamus	27.2 ± 2.9	30.5 ± 3.8	12	NS

^aSignificance: NS = not significant; t = 0.1 > p > 0.05; *p < 0.05; **p < 0.01; ***p < 0.001

ISSN: 1742-2094