Cytokine | Saline (3) | LPS (3) | LPS + indo (4) | Saline vs LPS | Saline vs LPS + indo | LPS vs LPS + indo |
---|---|---|---|---|---|---|
IL-1α | 2.5 ± 0.3 | 12.7 ± 1.9 | 17.9 ± 1.5 | ** | *** | * (indo increases) |
IL-1β | 19.7 ± 2.9 | 120.3 ± 39.8 | 34.6 ± 3.2 | * | NS | *(indo decreases) |
IL-2 | 15.8 ± 2.8 | 17.8 ± 2.1 | 27.3 ± 3.3 | NS | NS | NS |
IL-3 | 1.4 ± 0.2 | 2.1 ± 0.03 | 2.6 ± 0.16 | * | ** | NS |
IL-4 | 0.34 ± 0.02 | 0.92 ± 0.08 | 1.1 ± 0.05 | *** | *** | * (indo increases) |
IL-5 | 0.93 ± 0.07 | 1.2 ± 0.16 | 1.1 ± 0.1 | NS | NS | NS |
IL-6 | 1.5 ± 0.12 | 29.7 ± 16.5 | 72.8 ± 13.1 | NS | * | * (indo increases) |
IL-9 | 75.0 ± 3.1 | 156.9 ± 16.4 | 89.2 ± 7.0 | ** | NS | **(indo decreases) |
IL-10 | 6.3 ± 0.1 | 9.0 ± 0.3 | 10.4 ± 0.6 | ** | ** | NS |
IL-12(p40) | 8.5 ± 1.9 | 1084 ± 648.4 | 385.2 ± 81.8 | NS | NS | NS |
IL-12(p70) | 72.5 ± 6.5 | 102.1 ± 3.1 | 97.6 ± 10.3 | NS | NS | NS |
IL-13 | 38.1 ± 2.3 | 40.0 ± 3.5 | 27.7 ± 3.5 | NS | NS | NS |
IL-17 | 19.4 ± 2.3 | 24.8 ± 1.6 | 20.5 ± 0.9 | NS | NS | NS |
Eotaxin | 2213 ± 131.5 | 2671 ± 99.8 | 2165 ± 144.3 | NS | NS | NS |
GM-CSF | 28.6 ± 2.5 | 47.1 ± 1.3 | 43.9 ± 2.1 | ** | ** | NS |
IFN-γ | 16.1 ± 2.1 | 20.6 ± 1.1 | 22.9 ± 1.3 | NS | * | NS |
MCP-1 | 33.0 ± 4.6 | 1550 ± 300.6 | 1612 ± 275.1 | ** | ** | NS |
MIP-1a | 6.8 ± 0.7 | 128.3 ± 36.1 | 465.2 ± 108.4 | NS | * | * (indo increases) |
MIP-1b | 56.6 ± 3.5 | 128.9 ± 15.7 | 190.5 ± 37.0 | NS | * | NS |
RANTES | 1.5 ± 0.3 | 154.8 ± 37.7 | 280.1 ± 57.3 | NS | ** | NS |
TNF-α | 459.9 ± 34.3 | 482.1 ± 21.3 | 432.2 ± 16.7 | NS | NS | NS |