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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Epistasis analysis links immune cascades and cerebral amyloidosis

Fig. 2

T-maps of contrasts between genotypes. a T-statistical parametric maps (SPM) superimposed on an average structural MRI show brain regions with high SUVR values in carriers of the genetic interaction between the SNP rs261752 (C9 gene) and SNP rs7514452 (IL6r gene). Statistical differences overlap with brain regions vulnerable to AD pathophysiology. b SPM superimposed on an average structural MRI show the t-statistical contrast (CC(C9)*CC(IL6r) > CC(C9)*TT(IL6r)). Carriers of CC(C9)*CC(IL6r) have higher [18F]florbetapir SUVR in the frontal, parietal, and temporal cortices. c SPM superimposed on a structural MRI show the t-statistical contrast (CC(C9)*CC(IL6r) > TT(C9)*TC(IL6r)). CC(C9)*CC(IL6r) carriers have high [18F]florbetapir SUVR in brain regions typically affected by amyloidosis in Alzheimer’s disease. The analyses were adjusted for gender, diagnostic status, and ApoE ε4. The T value threshold of significance after RFT correction is ≥3.2 (p ≤ 0.05)

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