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Table 1 Demographic and key characteristics of the sample at baseline

From: Epistasis analysis links immune cascades and cerebral amyloidosis

  ADNI-GO/2 ADNI-1 Combined dataset
  Cognitively normal (CN) Mild cognitive impairment (MCI) Alzheimer’s disease (AD) Cognitively normal (CN) Mild cognitive impairment (MCI) Alzheimer’s disease (AD) Cognitively normal (CN) Mild cognitive impairment (MCI) Alzheimer’s disease (AD)
Number of subjects (%) 123 (29.6) 266 (64.9) 27 (6.5) 73 (42) 58 (33.3) 43 (24.7) 196 (33.2) 324 (54.9) 70 (11.9)
Number of males (%) 62 (50.4) 146 (54.9) 17 (63.0) 36 (49.3) 38 (65.5) 25 (58.1) 98 (50.0) 184 (56.8) 42 (60.0)
Number of ApoE ε4 carriers (%) 32 (26.0)a 118 (44.4)a 17 (63.0)a 19 (26) 21 (36.2) 27 (62.8)b 51 (26.0)a 139 (42.9)a 44 (62.9)a
Mean age (SD) 74.37 (5.62) 71.45 (7.61)b 75.56 (10.67) 80.73 (4.72) 79.64 (7.42) 76.47 (6.24)b 76.74 (6.12) 72.92 (8.19)b 76.12 (8.17)
Mean years of education (SD) 16.50 (2.64) 16.00 (2.55) 16.41 (2.32) 15.85 (2.92) 15.38 (3.17) 16.21 (2.66) 16.26 (2.76) 15.89 (2.67) 16.23 (2.49)
Mean CDR-SOB (SD) 0.03 (0.14)a 1.35 (0.86)a 4.70 (1.20)a 0.26 (0.8)a 1.73 (1.43)a 5.63 (3.28)a 0.12 (0.51)a 1.42 (0.99)a 5.26 (2.69)a
Mean MMSE (SD) 29.05 (1.16)a 28.23 (1.62)a 22.52 (1.88)a 29.03 (1.3)a 27.69 (1.88)a 21.44 (5.0)a 29.04 (1.21)a 28.13 (1.68)a 21.87 (4.13)a
Mean [18F]florbetapir SUVR (SD) 1.24 (0.20)a 1.31 (0.23)a 1.51 (0.24)a 1.15 (0.13)a 1.25 (0.18)a 1.40 (0.18)a 1.20 (0.19)a 1.30 (0.23)a 1.44 (0.21)a
  1. The baseline considered here is the date of the first [18F]florbetapir PET acquisition
  2. SD standard deviation, CDR-SOB Clinical Dementia Rating Scale Sum of Boxes, MMSE Mini-Mental State Examination, SUVR standard uptake value ratio
  3. aStatistically different between all groups from the same sample
  4. bStatistically different from the other groups from the same sample