From: Epistasis analysis links immune cascades and cerebral amyloidosis
 | ADNI-GO/2 | ADNI-1 | Combined dataset | ||||||
---|---|---|---|---|---|---|---|---|---|
 | Cognitively normal (CN) | Mild cognitive impairment (MCI) | Alzheimer’s disease (AD) | Cognitively normal (CN) | Mild cognitive impairment (MCI) | Alzheimer’s disease (AD) | Cognitively normal (CN) | Mild cognitive impairment (MCI) | Alzheimer’s disease (AD) |
Number of subjects (%) | 123 (29.6) | 266 (64.9) | 27 (6.5) | 73 (42) | 58 (33.3) | 43 (24.7) | 196 (33.2) | 324 (54.9) | 70 (11.9) |
Number of males (%) | 62 (50.4) | 146 (54.9) | 17 (63.0) | 36 (49.3) | 38 (65.5) | 25 (58.1) | 98 (50.0) | 184 (56.8) | 42 (60.0) |
Number of ApoE ε4 carriers (%) | 32 (26.0)a | 118 (44.4)a | 17 (63.0)a | 19 (26) | 21 (36.2) | 27 (62.8)b | 51 (26.0)a | 139 (42.9)a | 44 (62.9)a |
Mean age (SD) | 74.37 (5.62) | 71.45 (7.61)b | 75.56 (10.67) | 80.73 (4.72) | 79.64 (7.42) | 76.47 (6.24)b | 76.74 (6.12) | 72.92 (8.19)b | 76.12 (8.17) |
Mean years of education (SD) | 16.50 (2.64) | 16.00 (2.55) | 16.41 (2.32) | 15.85 (2.92) | 15.38 (3.17) | 16.21 (2.66) | 16.26 (2.76) | 15.89 (2.67) | 16.23 (2.49) |
Mean CDR-SOB (SD) | 0.03 (0.14)a | 1.35 (0.86)a | 4.70 (1.20)a | 0.26 (0.8)a | 1.73 (1.43)a | 5.63 (3.28)a | 0.12 (0.51)a | 1.42 (0.99)a | 5.26 (2.69)a |
Mean MMSE (SD) | 29.05 (1.16)a | 28.23 (1.62)a | 22.52 (1.88)a | 29.03 (1.3)a | 27.69 (1.88)a | 21.44 (5.0)a | 29.04 (1.21)a | 28.13 (1.68)a | 21.87 (4.13)a |
Mean [18F]florbetapir SUVR (SD) | 1.24 (0.20)a | 1.31 (0.23)a | 1.51 (0.24)a | 1.15 (0.13)a | 1.25 (0.18)a | 1.40 (0.18)a | 1.20 (0.19)a | 1.30 (0.23)a | 1.44 (0.21)a |