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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Amelioration of Japanese encephalitis by blockage of 4-1BB signaling is coupled to divergent enhancement of type I/II IFN responses and Ly-6Chi monocyte differentiation

Fig. 2

Enhanced development of innate NK cell responses in 4-1BB signal-ablated mice. a Absolute number of DC subpopulations. DC subpopulations (myeloid, lymphoid, and plasmacytoid DCs) were enumerated by flow cytometric analysis using collagenase-treated spleen 2 dpi. b Frequency and absolute number of NK cells. The frequency and number of CD3NK1.1+DX5+ NK cells were determined 2 dpi. Values in representative dot-plots denote the average percentage of NK cells after gating on CD3-negative cells. c NK cell activation. The activation of NK cells was evaluated by enumerating NK cells producing IFN-γ and granzyme B (GrB) using intracellular cytokine staining 2 dpi. Bar graphs show the average ± SD of values derived from at least four mice per group. *p < 0.05; **p < 0.01; ***p < 0.001 compared with the levels of the indicated groups

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