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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Amelioration of Japanese encephalitis by blockage of 4-1BB signaling is coupled to divergent enhancement of type I/II IFN responses and Ly-6Chi monocyte differentiation

Fig. 6

Virus control and IFN-I responses of 4-1BB signal-deficient myeloid cells to JEV infection. Primary bone marrow-derived DCs (BMDC) and macrophages (BMDM) recovered from WT and 4-1BB KO mice were infected with JEV at MOI of 1.0 and 10 for viral replication and 10 for cytokine expression. a, b JEV replication in BMDC and BMDM. c, d IFN-β and TNF-α expression in BMDC and BMDM. e, f Expression of RLR, IRF, and ISG genes in BMDC and BMDM. Bar charts show the average ± SD of values derived from BMDC and BMDM in quadruplicate. *p < 0.05; **p < 0.01; ***p < 0.001 compared with the levels of the indicated groups

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