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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Amelioration of Japanese encephalitis by blockage of 4-1BB signaling is coupled to divergent enhancement of type I/II IFN responses and Ly-6Chi monocyte differentiation

Fig. 7

Induction of IFN-I and ISGs in primary cortical neurons from 4-1BB signal-ablated mice after JEV infection. Primary cortical neurons generated from WT and 4-1BB KO mice were infected at MOI of 0.1, and viral replication and IFN-I responses were analyzed by real-time qRT-PCR at 24, 36, and 48 h pi. a JEV replication. b IFN-I expression. ce Induction of RLRs, IRFs, and ISGs. c ISGs. d RLRs. e IRFs. Bar charts show the average ± SD of values derived from primary cortical neurons in quadruplicate. *p < 0.05; **p < 0.01; ***p < 0.001 compared with the levels of the indicated groups

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