Fig. 8
Dominant role of HSCs derived from 4-1BB signal-ablated mice in ameliorating JE. BM cells from WT or 4-1BB KO mice were grafted to lethally irradiated WT or 4-1BB KO recipient mice, which were infected with JEV (3.0 × 107 PFU). a Susceptibility of 4-1BB KO BM chimeric models to JE. Infected recipient mice (n = 12) were examined over 21 days to determine survival rate. b Changes in body weight. Changes in body weight are expressed as the average percentage ± SD of body weight relative to the time of challenge. c Systemic IFN-β levels in 4-1BB KO BM chimeras. The amount of serum IFN-β was determined by ELISA at the indicated time points. Bar charts denote the average ± SD of values derived from at least five BM chimeras per group. **p < 0.01 compared with the levels of WT-KO BM chimera at 24 h pi. ## p < 0.01; ### p < 0.001 compared with the levels of WT-KO BM chimera at 48 h pi