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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: PET imaging studies show enhanced expression of mGluR5 and inflammatory response during progressive degeneration in ALS mouse model expressing SOD1-G93A gene

Fig. 4

Quantitative analysis of modulation of mGluR5 expression and inflammatory response in the spinal cord and lungs during progression of the disease. Comparison of mGluR5 expression and inflammatory response during progression of ALS-type degeneration in different parts of spinal cord and lungs shows enhancement in the accumulation of [18F]FPEB but significantly higher enhancement of [11C]PBR28 accumulation in the lumbar cord and lungs. The selected region of interest was the same for both studies. Quantitative values were calculated as percent of the injected activity in the tissue volume (cm3) since no reference tissue method can be used for inflammatory processes as well as no brain-related input function for peripheral mGluR5 expression. Mean values for accumulation were calculated from four base mice and four ALS-mice. Statistical analyses were done with student’s t test, and significances are marked to the figure (*p < 0.05 = , **p < 0.01 = , and ***p < 0.001 = )

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